the client is seeking a peptide drug discovery professional to oversee the design and optimization of therapeutic peptides, including PDCs and constrained macrocycles. The role will leverage structure-based and AI-driven approaches to advance candidates and support the development of peptide therapeutics with a focus on improving key drug-like properties.
Core responsibilities include optimizing peptide sequences for potency, selectivity, stability, solubility, permeability, and oral bioavailability. You will conduct SAR analysis, collaborate closely with chemistry and biology teams to iterate candidates, and use molecular modeling, docking, and pharmacophore analysis to study peptide–target binding. The role also involves supporting peptide synthesis and reaction optimization with synthetic chemists, as well as driving projects from hit identification through preclinical development and sharing research insights in cross-team meetings.
Successful applicants will typically hold a PhD in Medicinal Chemistry, Organic Chemistry, or a relevant field, with a strong background in small-molecule and peptide synthesis and drug design. Experience across drug discovery is expected, along with proficiency in structure-based drug design and ligand optimization, solid knowledge of peptide and protein–ligand interaction mechanisms, and strong problem-solving and teamwork skills for interdisciplinary collaboration. Familiarity with drug design and molecular visualization/modeling software may be expected.